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What's more, numerous effectively recognized adverse prognostic markers, including U-CLL, ATM aberrations or NOTCH1/BIRC3 mutations, misplaced their adverse outcome in people treated with VO. The only element that remained predictive of a shorter progression-totally free survival On this cohort of sufferers was TP53 aberrations.112 Eventually, the choice BTK inhibitor acalabrutinib was a short while ago authorised through the FDA (not with the EMA still) as frontline therapy in watch of the final results of a stage III trial evaluating acalabrutinib vs . ClbO.114

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